For adults with type 1 Gaucher disease, there are two ways to decrease the accumulation of fatty substances in the body. One way is by substrate reduction therapy, like ZAVESCA^®, where the production of fatty substances is limited or reduced.¹ The other way is enzyme replacement therapy (ERT), where man-made enzymes are added to the body to help break down the fatty substances.²

Yes. Studies with ZAVESCA^® included people who had never been treated with ERT as well as people who had previously taken imiglucerase, a kind of ERT, but who had stopped at least 6 months prior to taking ZAVESCA^®.¹

Within 6 to 12 months, people treated with ZAVESCA^® had improvements in 2 key areas¹:

• Significant mean percent reduction in the size of livers
• Significant mean percent reduction in size of spleens

Your doctor will generally monitor these key areas in addition to other tests to see how you’re responding to treatment.

Before you take ZAVESCA^® tell your doctor if you¹:

• have kidney problems
• have any other medical conditions
• are pregnant or plan to become pregnant. It is not known if ZAVESCA^® will harm your unborn baby
• are breastfeeding or plan to breastfeed. It is not known if ZAVESCA^® passes into your breast milk. Do not breastfeed during treatment with ZAVESCA^®. Talk to your healthcare provider about the best way to feed your baby during treatment with ZAVESCA^®

Tell your doctor about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. ZAVESCA^® may affect how other medicines work.¹

It’s important to take ZAVESCA^® as prescribed by your doctor. The recommended dosage of ZAVESCA^® is usually 1 pill (100 mg) taken 3 times each day.¹ In some cases, your doctor may have you take less, due to side effects like tremors and diarrhea.¹ Your doctor will determine the right dose for you. You should take ZAVESCA^® at the same time each day. If you miss a dose of ZAVESCA^®, skip that dose. Take the next ZAVESCA^® capsule at the usual time.¹ For example, if your prescription is for ZAVESCA^® 3 times a day, then take it when you first wake up, in the early afternoon, and before going to bed (or as close to 8-hour intervals as possible).

Some people experience fewer gastrointestinal disturbances when taking ZAVESCA^® without food or by changing their diet to avoid foods high in carbohydrates.¹ Talk with your doctor about what works best for you.